A general method applicable to the search for similarities in the amino acid sequence of two proteins¶
Why this mattered¶
TBD
Abstract¶
(no abstract available)
Related¶
- enables → Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade — Needleman-Wunsch sequence alignment made it possible to compare mismatch-repair genes and related protein sequences when characterizing repair-deficient tumors.
- enables → Identification of common molecular subsequences — Needleman-Wunsch dynamic programming for pairwise sequence alignment enabled Smith-Waterman local alignment to identify conserved molecular subsequences.
- enables → Improved tools for biological sequence comparison. — Needleman-Wunsch introduced dynamic-programming sequence alignment, which FASTA extended into faster practical tools for biological sequence comparison.
- enables → Basic local alignment search tool — Needleman-Wunsch framed sequence similarity as an alignment problem, while BLAST made local similarity search fast enough for large sequence databases.
- enables →
CHARMM : A program for macromolecular energy, minimization, and dynamics calculations — Needleman-Wunsch sequence alignment enabled CHARMM by supporting comparative protein sequence analysis used alongside macromolecular modeling. - cite ← Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade — The mismatch-repair study cites Needleman-Wunsch sequence alignment as a general method for comparing protein amino-acid sequences.
- cite ← Identification of common molecular subsequences — The common molecular subsequences paper builds on Needleman-Wunsch dynamic programming for sequence similarity by focusing on efficient identification of shared subsequences.
- cite ← Improved tools for biological sequence comparison. — FASTA improves on the Needleman-Wunsch dynamic programming method for detecting amino-acid sequence similarity.
- cite ← Basic local alignment search tool — BLAST uses the same biological goal as Needleman-Wunsch, identifying sequence similarity, but replaces full dynamic programming with local heuristic search.
- cite ←
CHARMM : A program for macromolecular energy, minimization, and dynamics calculations — CHARMM cites Needleman-Wunsch sequence alignment as a method for identifying homologous protein segments before structural modeling.