Biological insights from 108 schizophrenia-associated genetic loci¶
Why this mattered¶
TBD
Abstract¶
(no abstract available)
Related¶
- cite → LD Score regression distinguishes confounding from polygenicity in genome-wide association studies — LD Score regression provides a method to test whether the schizophrenia GWAS loci reflect true polygenic signal rather than population stratification or confounding.
- cite → A map of human genome variation from population-scale sequencing — The 1000 Genomes variation map supplies reference haplotypes and linkage disequilibrium structure used to interpret schizophrenia-associated loci.
- enables → The GTEx Consortium atlas of genetic regulatory effects across human tissues — The schizophrenia GWAS loci study motivated GTEx-style tissue-specific expression regulation analyses for assigning noncoding disease variants to genes and tissues.
- cite ← LD Score regression distinguishes confounding from polygenicity in genome-wide association studies — LD Score regression applies its method to schizophrenia GWAS results to show inflation from polygenic signal rather than only population confounding.
- cite ← The GTEx Consortium atlas of genetic regulatory effects across human tissues — The GTEx atlas uses schizophrenia GWAS loci as an example of how tissue-specific regulatory effects can help interpret disease-associated variants.